publication . Article . 2020

The origins and genomic diversity of American Civil War Era smallpox vaccine strains

Ana T. Duggan; Jennifer Klunk; Ashleigh F. Porter; Anna Dhody; Robert Hicks; Geoffrey L. Smith; Margaret Humphreys; Andrea M. McCollum; Whitni Davidson; Kimberly Wilkins; ...
Open Access English
  • Published: 20 Jul 2020 Journal: Genome Biology, volume 21, issue 1, pages 1-11
  • Publisher: BMC
  • Country: United Kingdom
Abstract
AbstractVaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with smallpox vaccination from historical artefacts. Significantly, we recover viral molecules through non-destructive sampling of historical materials lacking signs of biological residues. We use the authenticated ancient genomes to reveal the evolu...
Subjects
Medical Subject Headings: virusescomplex mixturesvirus diseases
Sustainable Development Goals: 3. Good health16. Peace & justice
Fields of Science and Technology classification: 03 medical and health sciences04 agricultural and veterinary sciences0403 veterinary science0303 health sciences040301 veterinary sciences030304 developmental biology
free text keywords: Vaccination, Smallpox, Vaccinia virus, Ancient DNA, Short Report, Humans, Vaccinia virus, Smallpox Vaccine, Vaccination, Genome, Viral, History, 19th Century, American Civil War, Genetic Variation, Metagenome, Humans, Smallpox Vaccine, Genome, Viral, History, 19th Century, American Civil War, Genetic Variation, Metagenome, lcsh:Biology (General), lcsh:QH301-705.5, lcsh:Genetics, lcsh:QH426-470, Smallpox, medicine.disease, medicine, Public health, medicine.medical_specialty, Ethnology, Diversity (politics), media_common.quotation_subject, media_common, Vaccination, Viral Vaccine, Biology, Smallpox vaccine, Ancient DNA, Spanish Civil War
Related Organizations
Funded by
SSHRC
Project
  • Funder: Social Sciences and Humanities Research Council (SSHRC)
,
WT
Project
  • Funder: Wellcome Trust (WT)
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
NSERC
Project
  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
,
SSHRC
Project
  • Funder: Social Sciences and Humanities Research Council (SSHRC)
Any information missing or wrong?Report an Issue