publication . Article . 2017

Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome

Warren A. Cheung; Xiaojian Shao; Andréanne Morin; Valérie Siroux; Tony Kwan; Bing Ge; Dylan Aïssi; Lu Chen; Louella Vasquez; Fiona Allum; ...
Open Access
  • Published: 10 Mar 2017
Abstract
Background The functional impact of genetic variation has been extensively surveyed, revealing that genetic changes correlated to phenotypes lie mostly in non-coding genomic regions. Studies have linked allele-specific genetic changes to gene expression, DNA methylation, and histone marks but these investigations have only been carried out in a limited set of samples. Results We describe a large-scale coordinated study of allelic and non-allelic effects on DNA methylation, histone mark deposition, and gene expression, detecting the interrelations between epigenetic and functional features at unprecedented resolution. We use information from whole genome and targ...
Subjects
ACM Computing Classification System: GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Medical Subject Headings: education
Fields of Science and Technology classification: 03 medical and health sciences0302 clinical medicine0301 basic medicine030217 neurology & neurosurgery030104 developmental biology
free text keywords: Research
Funded by
UKRI| Study of the interplay of genetic, biochemical, and lifestyle factors on coronary heart disease incidence
Project
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: G0800270
  • Funding stream: MRC
,
ANR| RESET-AID Consortium
Project
RESET-AID Consortium
REsolving Systems Epigenomes of T-cells from Autoimmune and Inflammatory Disease patients
  • Funder: French National Research Agency (ANR) (ANR)
  • Project Code: ANR-15-EPIG-0004
,
WT
Project
  • Funder: Wellcome Trust (WT)
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
UKRI| Study of the interplay of genetic, biochemical, and lifestyle factors on coronary heart disease incidence
Project
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: G0800270
  • Funding stream: MRC
Open Access
NARCIS
Article . 2017
Provider: NARCIS
Open Access
Genome Biology
Article . 2017
Open Access
Apollo
Article . 2017
Provider: Apollo
Supplementary Outcomes
20 research outcomes, page 1 of 2
20 research outcomes, page 1 of 2
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