publication . Article . 2014

Longitudinal Effects of Metabolic Syndrome on Alzheimer and Vascular Related Brain Pathology

Feng Lin; Raymond Y. Lo; Daniel Cole; Simon Ducharme; Ding-Geng Chen; Mark Mapstone; Anton P. Porsteinsson; Alzheimer's Disease Neuroimaging Initiative;
Open Access English
  • Published: 01 Jun 2014 Journal: Dementia and Geriatric Cognitive Disorders Extra, volume 4, issue 2, pages 184-194 (issn: 1664-5464, Copyright policy)
  • Publisher: Karger Publishers
Abstract
<b><i>Background/Aims:</i></b> This study examines the longitudinal effect of metabolic syndrome (MetS) on brain-aging indices among cognitively normal (CN) and amnestic mild cognitive impairment (aMCI) groups [single-domain aMCI (saMCI) and multiple-domain aMCI (maMCI)]. <b><i>Methods:</i></b> The study population included 739 participants (CN = 226, saMCI = 275, and maMCI = 238) from the Alzheimer's Disease Neuroimaging Initiative, a clinic-based, multi-center prospective cohort. Confirmatory factor analysis was employed to determine a MetS latent composite score using baseline data of vascular risk factors. We e...
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free text keywords: Metabolic syndrome, Alzheimer pathology, Mild cognitive impairment, Vascular pathology, Psychiatry and Mental health, Cognitive Neuroscience, Original Research Article, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429, lcsh:Geriatrics, lcsh:RC952-954.6, Pathology, medicine.medical_specialty, medicine, Confirmatory factor analysis, Neuroimaging, Temporal lobe, Psychology, Prospective cohort study, Disease, Population study, Fluorodeoxyglucose, medicine.drug, Metabolic syndrome, medicine.disease
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Funded by
NIH| The University of Rochester Clinical and Translational Science Institute
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5KL2TR000095-09
  • Funding stream: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
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