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Real-time functional photoacoustic remote sensing microscopy
Copyright policy )A fiber-tetherable non-contact photoacoustic remote sensing microscopy system capable of multiplex functional imaging is reported. By utilizing stimulated Raman scattering within an over-pumped polarization-maintaining single-mode optical fiber, rapid pulse-to-pulse switching (500 kHz) of excitation spectral content is demonstrated and utilized as a photoacoustic excitation source. These rapid acquisitions aim to reduce motion artifacts and facilitate high frame rates appropriate for real-time feedback to users. The system is characterized by estimating blood oxygen saturation in blood-flow phantoms and within a mouse ear in vivo.
Microsoft Academic Graph classification: Materials science Optical fiber Image quality Photoacoustic imaging in biomedicine Frame rate law.invention symbols.namesake law Microscopy symbols Multiplex Raman scattering Excitation Remote sensing
Atomic and Molecular Physics, and Optics
Atomic and Molecular Physics, and Optics
Microsoft Academic Graph classification: Materials science Optical fiber Image quality Photoacoustic imaging in biomedicine Frame rate law.invention symbols.namesake law Microscopy symbols Multiplex Raman scattering Excitation Remote sensing
- University of Alberta Canada
- University of Alberta Canada
A fiber-tetherable non-contact photoacoustic remote sensing microscopy system capable of multiplex functional imaging is reported. By utilizing stimulated Raman scattering within an over-pumped polarization-maintaining single-mode optical fiber, rapid pulse-to-pulse switching (500 kHz) of excitation spectral content is demonstrated and utilized as a photoacoustic excitation source. These rapid acquisitions aim to reduce motion artifacts and facilitate high frame rates appropriate for real-time feedback to users. The system is characterized by estimating blood oxygen saturation in blood-flow phantoms and within a mouse ear in vivo.