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Publication . Article . 2019

Real-time functional photoacoustic remote sensing microscopy

Kevan Bell; Parsin Haji Reza; Roger J. Zemp;
Published: 10 Jul 2019 Journal: Optics Letters, volume 44, page 3,466 (issn: 0146-9592, eissn: 1539-4794, Copyright policy )
Publisher: The Optical Society

A fiber-tetherable non-contact photoacoustic remote sensing microscopy system capable of multiplex functional imaging is reported. By utilizing stimulated Raman scattering within an over-pumped polarization-maintaining single-mode optical fiber, rapid pulse-to-pulse switching (500 kHz) of excitation spectral content is demonstrated and utilized as a photoacoustic excitation source. These rapid acquisitions aim to reduce motion artifacts and facilitate high frame rates appropriate for real-time feedback to users. The system is characterized by estimating blood oxygen saturation in blood-flow phantoms and within a mouse ear in vivo.

Subjects by Vocabulary

Microsoft Academic Graph classification: Materials science Optical fiber Image quality Photoacoustic imaging in biomedicine Frame rate law.invention symbols.namesake law Microscopy symbols Multiplex Raman scattering Excitation Remote sensing


Atomic and Molecular Physics, and Optics

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Funded by
  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
  • Funder: Canadian Institutes of Health Research (CIHR)
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