publication . Article . 2021

An atlas for human brain myelin content throughout the adult life span

Adam V. Dvorak; Taylor Swift-LaPointe; Irene M. Vavasour; Lisa Eunyoung Lee; Shawna Abel; Bretta Russell-Schulz; Carina Graf; Anika Wurl; Hanwen Liu; Cornelia Laule; ...
Open Access English
  • Published: 11 Jan 2021 Journal: Scientific Reports, volume 11, issue 1, pages 1-13 (issn: 2045-2322, Copyright policy)
  • Publisher: Nature Portfolio
Abstract
AbstractMyelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to create an optimized anatomical brain template and accompanying MWF and IET2 atlases. We then used the MWF atlas to characterize how myelin content relates to demographic factors. In most brain regions, myelin content followed a quadratic pattern of increase during the third decade of life, plateau at a maximum around the fifth decade, then ...
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Fields of Science and Technology classification: 03 medical and health sciences0302 clinical medicine030217 neurology & neurosurgery030218 nuclear medicine & medical imaging
Sustainable Development Goals: 2. Zero hunger
free text keywords: Medicine, R, Science, Q, Multidisciplinary, Article, Ageing, Magnetic resonance imaging, Myelin biology and repair, Neural ageing, Brain, Human brain, medicine.anatomical_structure, medicine, Context (language use), Myelin water fraction, Iron content, Myelin, Age groups, Neuroscience, Biology, Neuroimaging, Adult life
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  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
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