publication . Article . 2018

FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-π interactions

Seema Qamar; GuoZhen Wang; Suzanne J. Randle; Francesco Simone Ruggeri; Juan A. Varela; Julie Qiaojin Lin; Emma C. Phillips; Akinori Miyashita; Declan Williams; Florian Ströhl; ...
Open Access English
  • Published: 19 Apr 2018
  • Publisher: Elsevier
Abstract
Graphical Abstract
Subjects
Sustainable Development Goals: 2. Zero hunger3. Good health
Fields of Science and Technology classification: 03 medical and health sciences0302 clinical medicine0301 basic medicine030217 neurology & neurosurgery030104 developmental biology
free text keywords: AFM-IR, Arginine methylation, Cation-π, Citrullination, Frontotemporal dementia, Membraneless organelle, Neuronal ribonucleoprotein granule, Phase separation, Phase-sensitive fluorescent dyes, Synaptic new protein synthesis, AFM-IR, Arginine methylation, Cation-π, Citrullination, Frontotemporal dementia, Membraneless organelle, Neuronal ribonucleoprotein granule, Phase separation, Phase-sensitive fluorescent dyes, Synaptic new protein synthesis, Animals, Xenopus laevis, Humans, Amyotrophic Lateral Sclerosis, Cations, Arginine, Tyrosine, RNA-Binding Protein FUS, Molecular Chaperones, Microscopy, Fluorescence, Microscopy, Atomic Force, DNA Methylation, Protein Processing, Post-Translational, Protein Structure, Secondary, Protein Binding, Frontotemporal Lobar Degeneration, Protein Domains, QD Chemistry, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, DAS, BDC, R2C, ~DC~, QD, RC0321, Article, General Biochemistry, Genetics and Molecular Biology, Animals, Xenopus laevis, Humans, Amyotrophic Lateral Sclerosis, Cations, Arginine, Tyrosine, RNA-Binding Protein FUS, Molecular Chaperones, Microscopy, Fluorescence, Microscopy, Atomic Force, DNA Methylation, Protein Processing, Post-Translational, Protein Structure, Secondary, Protein Binding, Frontotemporal Lobar Degeneration, Protein Domains, Ribonucleoprotein, Function (biology), Arginine, Organelle, Methylation, Protein biosynthesis, Biophysics, Citrullination, Biology, Neuronal ribonucleoprotein granule
Communities
Funded by
EC| AXONSURVIVAL
Project
AXONSURVIVAL
Axon survival: the role of protein synthesis
  • Funder: European Commission (EC)
  • Project Code: 322817
  • Funding stream: FP7 | SP2 | ERC
,
WT
Project
  • Funder: Wellcome Trust (WT)
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
EC| RIBOMYLOME
Project
RIBOMYLOME
The Role of Non-coding RNA in Protein Networks and Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 309545
  • Funding stream: FP7 | SP2 | ERC
,
EC| AXONSURVIVAL
Project
AXONSURVIVAL
Axon survival: the role of protein synthesis
  • Funder: European Commission (EC)
  • Project Code: 322817
  • Funding stream: FP7 | SP2 | ERC
Open Access
Cell
Article . 2018
Open Access
Cell
Article
Provider: UnpayWall
Open Access
Cell
Article . 2018
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